Search results
Results From The WOW.Com Content Network
Before their use in chemotherapy, alkylating agents were better known for their use as sulfur mustard, ("mustard gas") and related chemical weapons in World War I. The nitrogen mustards were the first alkylating agents used medically, as well as the first modern cancer chemotherapies. Goodman, Gilman, and others began studying nitrogen mustards ...
Electrophilic, soluble alkylating agents are often toxic and carcinogenic, due to their tendency to alkylate DNA. This mechanism of toxicity is relevant to the function of anti-cancer drugs in the form of alkylating antineoplastic agents. Some chemical weapons such as mustard gas (sulfide of dichloroethyl) function as alkylating agents ...
Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle. [ 1 ] Alkylating antineoplastic agent and anthracyclins are two examples.
1.09 Alkylating agents: Altretamine: PO Alkylates DNA. Recurrent or advanced ovarian cancer Myelosuppression, peripheral neuropathy, seizures and hepatotoxicity (rare). Bendamustine: IV: Alkylates DNA. Chronic lymphocytic leukaemia, mantle cell lymphoma and non-Hodgkin's lymphoma. Myelosuppression, hypokalaemia and tachycardia. Busulfan: IV, PO ...
For this reason, the effect on the cell is dose dependent; the fraction of cells that die is directly proportional to the dose of drug. [39] The subtypes of alkylating agents are the nitrogen mustards, nitrosoureas, tetrazines, aziridines, [40] cisplatins and derivatives, and non-classical alkylating
Cyclophosphamide is in the alkylating agent and nitrogen mustard family of medications. [4] It is believed to work by interfering with the duplication of DNA and the creation of RNA. [4] Cyclophosphamide was approved for medical use in the United States in 1959. [4] It is on the World Health Organization's List of Essential Medicines. [6]
Carmustine is used as an alkylating agent to treat several types of brain cancer including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma, multiple myeloma, and lymphoma (Hodgkin's and non-Hodgkin). Carmustine is sometimes used in conjunction with alkyl guanine transferase (AGT) inhibitors, such as O 6-benzylguanine.
Melphalan belongs to the class of nitrogen mustard alkylating agents. [7] It works by interfering with the creation of DNA and RNA. [7] Melphalan was approved for medical use in the United States in 1964. [7] It is on the World Health Organization's List of Essential Medicines. [9] It is available as a generic medication. [10]