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Metformin is a tool to support lifestyle changes for conditions including type 2 diabetes and PCOS and is best used in conjunction with regular exercise, following a balanced diet, good sleep ...
Early trials in women with PCOS found that metformin helped give a small benefit in insulin sensitivity, reduced weight and helped restore periods, Dr. Ohri says. Because of this, metformin is ...
At least 65% to 80% of people with PCOS live with insulin resistance as well. Further, individuals with PCOS and excess weight tend to experience worse medical outcomes than women with PCOS and a ...
A systematic review and meta-analysis in 2012 [16] concluded that there is insufficient evidence to establish a difference between metformin and clomiphene citrate in terms of ovulation, pregnancy, live birth, miscarriage, and multiple pregnancy rates in women with PCOS and a BMI less than 32 kg/m 2. [16]
A Cochrane review, though, found that metformin was only slightly effective for decreasing androgen levels in women with PCOS. [125] Metformin also has significant effects on the gut microbiome, such as its effect on increasing agmatine production by gut bacteria, but the relative importance of this mechanism compared to other mechanisms is ...
Insulin resistance in women with PCOS is typically treated with insulin-sensitizer drugs such as metformin. Metformin can help to decrease weight and androgen levels. [72] When combined with lifestyle modifications (changes in diet and exercise), it has been linked with lower body mass index and a reduction in menstrual problems. [72]