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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes permanent symptoms of Parkinson's disease. (–)-Mitragynine is a naturally occurring tetrahydropyridine. 2,3,4,5-Tetrahydropyridine, a colorless liquid, is commercially available. It is an imine. Illustrating another isomer of tetrahydropyridine, 6-acetyl-2,3,4,5-tetrahydropyridine occurs ...
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound.It is classified as a tetrahydropyridine.It is of interest as a precursor to the monoaminergic neurotoxin MPP +, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain.
Baikiain is an organic compound with the molecular formula C 6 H 9 NO 2.Chemically, it is classified as a tetrahydropyridine substituted with a carboxylic acid.Because it contains both this carboxylic acid and an adjacent amine group, it is also an alpha-amino acid. [1]
[8] [9] A close analogue of 2′-CH 3-MPTP is 2′-NH 2-MPTP, which, in contrast to 2′-CH 3-MPTP and MPTP, is a serotonergic and noradrenergic neurotoxin with no effect on dopaminergic neurons. [10] Numerous other neurotoxic MPTP analogues have also been synthesized. [8] 2′-CH 3-MPTP was first described in the scientific literature by 1986. [4]
2′-NH 2-MPTP, also known as 2′-amino-MPTP, is a monoaminergic neurotoxin that was derived from MPTP and is used in scientific research to lesion brain monoaminergic systems in animals. [ 1 ] [ 2 ] Whereas MPTP is a selective dopaminergic neurotoxin , 2′-NH 2 -MPTP is a specific serotonergic and noradrenergic neurotoxin that does not ...
6-Acetyl-2,3,4,5-tetrahydropyridine is an aroma compound and flavor that gives baked goods such as white bread, popcorn, and tortillas their typical smell, together with its structural homolog 2-acetyl-1-pyrroline. 6-Acetyl-2,3,4,5-tetrahydropyridine and 2-acetyl-1-pyrroline are usually formed by Maillard reactions during heating of food. Both ...
Methylphenyltetrahydropyridine N-monooxygenase (EC 1.13.12.11) is an enzyme with systematic name 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase. [1] This enzyme catalyses the following chemical reaction
Guvacine is a tetrahydropyridine alkaloid found in areca nuts. [1] It is the N-demethylated derivative of arecaidine and the product of ester hydrolysis of guvacoline, both of which are also found in areca nuts as well. It is also an inhibitor of gamma-aminobutyric acid uptake. Lime hydrolyzes guvacoline to guvacine. [2]