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OSU-03012 (AR-12) is a celecoxib derivative with anticancer and anti-microbial activity. Unlike celecoxib, OSU-03012 does not inhibit COX, but inhibits several other important enzymes instead which may be useful in the treatment of some forms of cancer, [1] [2] When combined with PDE5 inhibitors such as sildenafil or tadalafil, OSU-03012 was found to show enhanced anti-tumour effects in cell ...
The AR-15 rifle usually comes chambered for either the military cartridge 5.56×45mm or the .223 Remington. Because of the pressures associated with the 5.56×45mm, it is not advisable to fire 5.56×45mm rounds in an AR-15 marked as .223 Remington, since this can result in damage to the rifle or injury to the shooter. [1]
The AR-15 is nominally chambered in .223 Remington or 5.56×45mm NATO, with the .223 Wylde chamber allowing for the safe chambering of both, but many variants have been produced in different calibers such as .22 LR (sometimes referred to as an AR-22 [59]), 7.62×39mm, 9×19mm Parabellum, [60] 6.5mm Grendel, and shotgun calibers. [61]
The Armalite AR-15 is the parent of a variety of Colt AR-15 and M16 rifle variants. History After World War II, the United States military started looking for a single automatic rifle to replace the M1 Garand , M1/M2 Carbines , M1918 Browning Automatic Rifle , M3 "Grease Gun" and Thompson submachine gun .
A smaller version of the AR-10 and adopted by the United States military as the M16 rifle. Later developed by Colt into a popular semi-automatic Colt AR-15. AR-16: 7.62×51mm NATO: ArmaLite: Prototype battle rifle. ArmaLite AR-17: 12 gauge: Semiautomatic 12ga 2shot shotgun based on the earlier AR-9. AR-18: 5.56×45mm NATO
ArmaLite, or Armalite, is an American small arms engineering company, formed in the early 1950s in Hollywood, California.Many of its products, as conceived by chief designer Eugene Stoner, relied on unique foam-filled fiberglass butt/stock furniture and a composite barrel using a steel liner inside an aluminum sleeve, including the iconic AR-15/M16 family.
This was due to the availability cheap surplus Communist Bloc 5.45mm ammunition and AK-series weapons. [11] It had a 16-inch barrel, 6-position collapsible stock and a stainless-steel 30-round magazine. However, few shooters wanted an expensive AR-15 clone in a non-standard caliber that needed special magazines. [11]
With normal bullet weights between 300 and 400 grains (19 and 26 g), overall cartridge length shorter than that of an AR-15 magazine well, and holding to pressures of 33,000 psi limited by the AR bolt strength system, [2] the .50 Beowulf is best described as a low-velocity, heavy caliber, making its ballistics roughly equivalent to those of ...