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  2. Saturation mutagenesis - Wikipedia

    en.wikipedia.org/wiki/Saturation_mutagenesis

    Additionally, it is usual to use degenerate codons that minimise stop codons (which are generally not desired). Consequently, the fully randomised 'NNN' is not ideal, and alternative, more restricted degenerate codons are used. 'NNK' and 'NNS' have the benefit of encoding all 20 amino acids, but still encode a stop codon 3% of the time.

  3. Codon degeneracy - Wikipedia

    en.wikipedia.org/wiki/Codon_degeneracy

    Degeneracy or redundancy [1] of codons is the redundancy of the genetic code, exhibited as the multiplicity of three-base pair codon combinations that specify an amino acid. The degeneracy of the genetic code is what accounts for the existence of synonymous mutations . [ 2 ] :

  4. Codon usage bias - Wikipedia

    en.wikipedia.org/wiki/Codon_usage_bias

    Codon usage bias in Physcomitrella patens. Codon usage bias refers to differences in the frequency of occurrence of synonymous codons in coding DNA. A codon is a series of three nucleotides (a triplet) that encodes a specific amino acid residue in a polypeptide chain or for the termination of translation (stop codons).

  5. Degeneracy (biology) - Wikipedia

    en.wikipedia.org/wiki/Degeneracy_(biology)

    Examples of degeneracy are found in the genetic code, when many different nucleotide sequences encode the same polypeptide; in protein folding, when different polypeptides fold to be structurally and functionally equivalent; in protein functions, when overlapping binding functions and similar catalytic specificities are observed; in metabolism, when multiple, parallel biosynthetic and ...

  6. Genetic saturation - Wikipedia

    en.wikipedia.org/wiki/Genetic_Saturation

    Although it’s possible to code for all 20 amino acids, this is not the most efficient method. The most efficient method is to use an NNK codon degeneracy, also known as a limited codon set. [12] This method, will result in only 32 codons rather than 64. [10]

  7. Genetic code - Wikipedia

    en.wikipedia.org/wiki/Genetic_code

    For each codon (square brackets), the amino acid is given by the vertebrate mitochondrial code, either in the +1 frame for MT-ATP8 (in red) or in the +3 frame for MT-ATP6 (in blue). The MT-ATP8 genes terminates with the TAG stop codon (red dot) in the +1 frame. The MT-ATP6 gene starts with the ATG codon (blue circle for the M amino acid) in the ...

  8. NYT ‘Connections’ Hints and Answers Today, Saturday, February 15

    www.aol.com/nyt-connections-hints-answers-today...

    We mean it. Read no further until you really want some clues or you've completely given up and want the answers ASAP. Get ready for all of today's NYT 'Connections’ hints and answers for #615 on ...

  9. Synonymous substitution - Wikipedia

    en.wikipedia.org/wiki/Synonymous_substitution

    This is possible because the genetic code is "degenerate", meaning that some amino acids are coded for by more than one three-base-pair codon; since some of the codons for a given amino acid differ by just one base pair from others coding for the same amino acid, a mutation that replaces the "normal" base by one of the alternatives will result ...