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Croup (/ k r uː p / KROOP), also known as croupy cough, is a type of respiratory infection that is usually caused by a virus. [2] The infection leads to swelling inside the trachea , which interferes with normal breathing and produces the classic symptoms of "barking/brassy" cough, inspiratory stridor and a hoarse voice . [ 2 ]
The usual dose by mouth is one capsule of 250 mg 4 times a day in adults and half the adult dose as a syrup for children under the age of 10 years but over 2. [4] For children below the age of 2 years, the oral dose is a quarter of the adult oral dose. [3] Ampicillin/flucloxacillin is taken orally about half an hour before food. [5]
Antibiotics with less reliable but occasional (depending on isolate and subspecies) activity: occasionally penicillins including penicillin, ampicillin and ampicillin-sulbactam, amoxicillin and amoxicillin-clavulnate, and piperacillin-tazobactam (not all vancomycin-resistant Enterococcus isolates are resistant to penicillin and ampicillin)
Some cough medicines may be no more effective than placebos for acute coughs in adults, including coughs related to upper respiratory tract infections. [7] The American College of Chest Physicians emphasizes that cough medicines are not designed to treat whooping cough , a cough that is caused by bacteria and can last for months. [ 8 ]
Ambroxol is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. Ambroxol is often administered as an active ingredient in cough syrup. It was patented in 1966 and came into medical use in 1979. [1]
Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. but with an N-oxime side chain attached to the ring. Roxithromycin was patented in 1980 and approved for medical use in 1987. [1]