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The US Food and Drug Administration (FDA) first approved the use of intranasal esketamine —an enantiomer of ketamine—for the use of ketamine-derived therapy for treatment-resistant depression, in 2019, [11] leading to the creation and expansion of telemedicine-based companies that practice KAP, such as Mindbloom. [12]
Medicare does not typically cover ketamine infusions for mental health conditions. However, it may cover Spravato, an FDA-approved drug deriving from ketamine, for treatment-resistant depression.
Since depression comes in many forms, treating this mental health condition isn’t a one-size-fits-all approach. With a wide variety of treatment methods, it can take time to find the one that ...
Spravato is made from esketamine, which is derived from ketamine—a Schedule III drug that’s FDA-approved as an anesthetic (and often abused) but has shown promise as an off-label IV treatment ...
These estimates are based on limited available research. [66] In February 2022, the US Food and Drug Administration issued an alert to healthcare professionals concerning compounded nasal spray products containing ketamine intended to treat depression. [67]
[33] [34] [35] According to a 2018 review, ketamine showed more than double the antidepressant effect size over placebo of conventional antidepressants in the treatment of depression based on the preliminary evidence available at the time (Cohen's d = 1.3–1.7 for ketamine, Cohen's d = 0.8 for midazolam (active placebo), and Cohen's d = 0.53 ...
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