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Systemic Histiocytosis (SH) was originally recognized in closely related Bernese Mountain Dogs. SH is a generalized histiocytic proliferative disease with a marked tendency to involve skin, ocular and nasal mucosa, and peripheral lymph nodes.
Progression of a Histocytoma on a French Bulldog Ear -2 months time A histiocytoma on the ear of a dog Canine Cutaneous Histiocytoma on a young boxer dog. A histiocytoma in the dog is a benign tumor. It is an abnormal growth in the skin of histiocytes (histiocytosis), a cell that is part of the immune system.
Malignant histiocytosis is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. Histiocytes are a component of the immune system that proliferate abnormally in this disease. In addition ...
Histiocytosis is a rare group of disorders that involve a build up of histiocytes in tissue and organs, causing damage to the tissue or organ. It may be benign or malignant. [31] Malignant histiocytosis is a rapidly progressive multisystem cancerous disease that affects the Bernese Mountain Dog.
Sinus histiocytosis, a common feature in lymph node biopsies, is characterized by dilated sinuses containing variable numbers of histiocytes. [ 4 ] Histiocytosis is a rare disease, thus its diagnosis may be challenging.
The Rottweiler is prone to several skin conditions these include: acral lick dermatitis, calcinosis cutis, lupoid onychodystrophy, malignant histiocytic sarcoma, systemic histiocytosis, vasculopathy, and vitiligo. [24] Follicular lipidosis is a skin condition found in red point dogs such as the Rottweiler. [25]
Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Symptoms range from isolated bone lesions to multisystem disease . [ 1 ]
Malignant histiocytosis (histiocytic sarcoma) is an aggressive cancer found primarily in certain breeds including the Bernese Mountain Dog, rottweiler, golden retriever and flat coated retriever. It is characterized by infiltration of the joints, lungs, spleen , lymph nodes , and other organs by malignant histiocytes .