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The costamere is a structural-functional component of striated muscle cells [1] which connects the sarcomere of the muscle to the cell membrane (i.e. the sarcolemma). [ 2 ] Costameres are sub-sarcolemmal protein assemblies circumferentially aligned in register with the Z-disk of peripheral myofibrils .
A sarcomere (Greek σάρξ sarx "flesh", μέρος meros "part") is the smallest functional unit of striated muscle tissue. [1] It is the repeating unit between two Z-lines. Skeletal muscles are composed of tubular muscle cells (called muscle fibers or myofibers) which are formed during embryonic myogenesis.
Land added to Laurentia during the Grenville orogeny. The first mountain-building tectonic plate collision that initiated the construction of what are today the Appalachian Mountains occurred during the Mesoproterozoic era at least one billion years ago when the pre-North-American craton called Laurentia collided with other continental segments, notably Amazonia.
Valley and Ridge province as part of the Appalachian Highlands division, based on the U.S. Geological Survey physiographic classification. The Ridge-and-Valley Appalachians, also called the Ridge and Valley Province or the Valley and Ridge Appalachians, are a physiographic province of the larger Appalachian Highlands division.
Blue Ridge Mountains - Front Royal, Virginia Although the term "Blue Ridge" is sometimes applied exclusively to the eastern edge or front range of the Appalachian Mountains, the geological definition of the Blue Ridge province extends westward to the Ridge and Valley area, encompassing the Great Smoky Mountains, the Great Balsams, the Roans, the Blacks, and other mountain ranges.
The Appalachian region is made up of 13 states, including parts of Ohio, Pennsylvania, Kentucky, Virginia, Tennessee and the Carolinas. West Virginia — where Terra Vance was born and raised ...
Vance's mother's parents, Bonnie Blanton and Jim Vance Sr., whom he called Mamaw and Papaw, were from Jackson, Kentucky, a city of around 2,100 people in the Appalachian region.
For instance, parts of Alabama and Mississippi were included in the commission because of problems with unemployment and poverty similar to those in Appalachia proper, and the ARC region extends into the Northeastern states, which are not traditionally considered part of Appalachia culturally (though a "northern Appalachia" identity has emerged ...