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Sarcoidosis is a disease of unknown cause characterized by non-necrotizing ("non-caseating") granulomas in multiple organs and body sites, [12] most commonly the lungs and lymph nodes within the chest cavity. Other common sites of involvement include the liver, spleen, skin, and eyes.
Erythema nodosum (EN) is an inflammatory condition characterized by inflammation of subcutaneous fat tissue, resulting in painful red/blue lumps or nodules that are usually seen symmetrically on both shins, on the thighs, arms, and elsewhere. [1] It can be caused by a variety of conditions but 20 to 50% of cases are idiopathic.
However, inguinal lymph nodes of up to 15 mm and cervical lymph nodes of up to 20 mm are generally normal in children up to age 8–12. [38] Lymphadenopathy of more than 1.5–2 cm increases the risk of cancer or granulomatous disease as the cause rather than only inflammation or infection. Still, an increasing size and persistence over time ...
Local cancer in many parts of the body can cause lymph nodes to enlarge because of tumorous cells that have metastasised into the node. [33] Lymph node involvement is often a key part in the diagnosis and treatment of cancer, acting as "sentinels" of local disease, incorporated into TNM staging and other cancer staging systems.
Nodules in skin include dermatofibroma [5] and pyogenic granuloma. [6] Nodules may form on tendons and muscles in response to injury, [ 7 ] and are frequently found on vocal cords . [ 8 ] They may occur in organs such as the lung , [ 9 ] or thyroid , [ 10 ] or be a sign in other medical conditions such as rheumatoid arthritis .
Lymph nodes may become enlarged in malignant disease. This cervical lymphadenopathy may be reactive or metastatic. [1] Alternatively, enlarged lymph nodes may represent a primary malignancy of the lymphatic system itself, such as lymphoma (both Hodgkin's and non-Hodgkin's), [6] lymphocytic leukemia, [1] Lymphadenopathy that lasts less than two weeks or more than one year with no progressive ...
The most common lesions are erythema nodosum, plaques, maculopapular eruptions, subcutaneous nodules, and lupus pernio. [33] Treatment is not required, since the lesions usually resolve spontaneously in 2–4 weeks. Although it may be disfiguring, cutaneous sarcoidosis rarely causes major problems.
Lymph nodes are located at intervals along the lymphatic system. Several afferent lymph vessels bring in lymph, which percolates through the substance of the lymph node, and is then drained out by an efferent lymph vessel. Of the nearly 800 lymph nodes in the human body, about 300 are located in the head and neck. [23]