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Gonorrhea is the second most common STI in the U.S. and has developed resistance to all antibiotics used to treat it, except for the recommended combined therapy of an injection of the antibiotic ...
The Canadian report called antibiotic-resistant gonorrhea “a serious public health threat” and said the STI’s ability to withstand two antibiotics used to treat it, ceftriaxone and ...
Gonorrhea can be prevented with the use of condoms, having sex with only one person who is uninfected, and by not having sex. [1] [3] Treatment is usually with ceftriaxone by injection and azithromycin by mouth. [4] [5] Resistance has developed to many previously used antibiotics and higher doses of ceftriaxone are occasionally required. [4] [5]
Efflux pumps mediate resistance to a variety of compounds including antibiotics, detergents, and dyes. [2] This mechanism falls under the first general resistance mechanism to beta-lactams. mtr encodes for the protein MtrD which is the efflux pump for N. gonorrhoeae. [2] MtrD is among the Resistance Nodulation Division (RND) efflux pump ...
Within N. gonorrhoeae, genes exist that confer resistance to every single antibiotic used to cure gonorrhea, but thus far they do not coexist within a single gonococcus. However, because of N. gonorrhoeae ' s high affinity for horizontal gene transfer, antibiotic-resistant gonorrhea is seen as an emerging public health threat. [81]
The strain was found to resist five classes of antibiotics, a first in the U.S., according to the Massachusetts Dept. of Public Health (DPH).
This condition occurs in 0.5-3% of individuals with gonorrhea, and it usually presents 2–3 weeks after acquiring the infection. [6] Risk factors include female sex, sexual promiscuity, and infection with resistant strains of Neisseria gonorrhoeae. This condition is treated with cephalosporin and fluoroquinolone antibiotics. [5]
If symptoms persist, follow-up with a urologist may be necessary to identify the cause. According to a study, tinidazole used with doxycycline or azithromycin may cure NGU better than when doxycycline or azithromycin is used alone. [8] If left untreated, complications include epididymitis and infertility.