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In broad usage, the "practical clinical significance" answers the question, how effective is the intervention or treatment, or how much change does the treatment cause. In terms of testing clinical treatments, practical significance optimally yields quantified information about the importance of a finding, using metrics such as effect size, number needed to treat (NNT), and preventive fraction ...
Korotkov described 5 sounds. Only the first (the onset of audible sound, and corresponding to systolic pressure) and the fifth (sound becomes inaudible, corresponding to diastolic pressure) are of practical clinical significance (however, see:Auscultatory gap) Kussmaul breathing [5] Adolph Kussmaul: endocrinology: metabolic acidosis
Such a small difference could be irrelevant (i.e., of no clinical importance) to patients or clinicians. Thus, statistical significance does not necessarily imply clinical importance. Over the years clinicians and researchers have moved away from physical and radiological endpoints towards patient-reported outcomes.
It has been used in clinical studies to investigate life pre and post surgery, [53] psychiatric disorders [54] and the subjective handicap of epilepsy. [55] Eye disease. The National Eye Institute Visual Function (VFQ-25) is a 25-item questionnaire designed to assess eye health, intended for use in clinical studies. [56]
The survey is composed of physical examinations by the doctor's senses and simple medical devices, which build clinical findings. If necessary, the results are proofed by further diagnostic tests , which may include procedures using medical apparatus.
Off label indications often have some clinical significance to back the use, but they have not gone through the extensive testing required by the FDA to have an official labeled indication. Drug companies can not provide any official medication information (e.g. package inserts ) for off label indications.
Clinical significance – a conclusion that an intervention has an effect that is of practical meaning to patients Drug discovery – the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy
An example of a triad is Meltzer's triad presenting purpura a rash, arthralgia painful joints, and myalgia painful and weak muscles. Meltzer's triad indicates the condition cryoglobulinemia . Huntington's disease is a neurodegenerative disease that is characterized by a triad of motor, cognitive, and psychiatric signs and symptoms. [ 31 ]