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A steady-state plasma level of dofetilide is achieved in 2–3 days. 80% of dofetilide is excreted by the kidneys, so the dose of dofetilide should be adjusted in individuals with chronic kidney disease, based on creatinine clearance. In the kidneys, dofetilide is eliminated via cation exchange (secretion).
Social sciences including anthropology, ethnography, and archaeology have long investigated human interactions with living things. Anthropology and ethnography have traditionally studied these interactions in two opposed ways: as physical resources that humans used; [3] and as symbols or concepts through totemism and animism. [5]
Yeasts have been used since ancient times to leaven bread and to ferment beer and wine. [2] More recently, fungi have been used for a wide variety of industrial fermentations, whether working directly for their effects on materials such as processing paper pulp or bioremediating industrial waste, or serving as the source of enzymes for many purposes, such as fading and softening denim for ...
Bictegravir should not be used with dofetilide and rifampin. [16] Use of dofetilide with bictegravir increases the concentration of dofetilide, which can lead to life-threatening events. [ 16 ] Concomitant use of bictegravir and rifampin causes significant interactions because of an effect rifampin has on bictegravir. [ 16 ]
Human interactions with microbes include both practical and symbolic uses of microbes, and negative interactions in the form of human, domestic animal, and crop diseases. Practical use of microbes began in ancient times with fermentation in food processing ; bread , beer and wine have been produced by yeasts from the dawn of civilisation, such ...
Commercial DDT is a mixture of several closely related compounds. Due to the nature of the chemical reaction used to synthesize DDT, several combinations of ortho and para arene substitution patterns are formed. The major component (77%) is the desired p,p ' isomer. The o,p ' isomeric impurity is also present in significant amounts (15%).
Human impact on the environment (or anthropogenic environmental impact) refers to changes to biophysical environments [1] and to ecosystems, biodiversity, and natural resources [2] caused directly or indirectly by humans. Modifying the environment to fit the needs of society (as in the built environment) is causing severe effects [3] [4 ...
Mexiletine (sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, headache, and nausea.