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Impaired immunity in part drive disease progression after SARS-CoV-2 infection. [25] While health agency guidelines tend to recommend isolating for 14 days while watching for symptoms to develop, [ 26 ] there is limited evidence that symptoms may develop for some patients more than 14 days after initial exposure.
As of April 2020 trials were investigating whether existing medications could be used effectively against the body's immune reaction to SARS-CoV-2 infection. [44] [45] As of May 2020 several antiviral drugs were under investigation for COVID-19, though none had been shown to be clearly effective on mortality in published randomized controlled ...
SARS‑CoV‑2 is a strain of the species Betacoronavirus pandemicum (SARSr-CoV), as is SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak. [ 2 ] [ 17 ] There are animal-borne coronavirus strains more closely related to SARS-CoV-2, the most closely known relative being the BANAL-52 bat coronavirus.
Severe acute respiratory syndrome (SARS) Severe acute respiratory syndrome coronavirus (SARS‑CoV or SARS‑CoV‑1), a strain of severe acute respiratory syndrome–related coronavirus (SARSr‑CoV) 2002 Discovered in Foshan, China. [29] Caused the 2002–2004 SARS outbreak. Possibly originated from horseshoe bats. [30] Humans Common cold
A novel coronavirus, named Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. The illness caused by this virus has been named coronavirus disease 2019 (COVID-19).
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About 44% of those infected with SARS-CoV-2 remained asymptomatic throughout the infection. [28] People who are asymptomatic do not show symptoms but still are able to transmit the virus. [12] At least a third of the people who are infected with the virus do not develop noticeable symptoms at any point in time.
X-ray crystal structure (PDB:7SI9 and 7VH8) of the SARS-CoV-2 protease inhibitor nirmatrelvir bound to the viral 3CLpro protease enzyme. Ribbon diagram of the protein with the drug shown as sticks. The catalytic residues (His41, Cys145) are shown as yellow sticks.