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Prednisolone has a relatively short half-life, ranging 2–4 hours. It also has a large therapeutic window, considering the dosage required to produce a therapeutic effect is a few times higher than what the body naturally produces. [14] Prednisolone is 70–90% plasma protein bound, it binds to proteins such as albumin. [14]
Prednisolone acetate is acutely toxic with an LD50 of >240 mg/kg for a rat and 3500 mg/kg for a mouse. Effects may present delayed. Target organs include adrenal cortex, bones, and eyes. It is also a known teratogen. [3] Class B PPE should be worn when working with this chemical. Any contact with this chemical should be taken seriously and the ...
[4] [3] It is generally considered safe in pregnancy and low doses appear to be safe while the user is breastfeeding. [5] After prolonged use, prednisone must be stopped gradually. [3] Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active.
For example, prednisone is used at low doses (equal to or less than 7.5 mg per day), medium doses (greater than 7.5 mg but less than 30 mg per day), or high doses (greater than 30 mg but less than 100 mg per day) to treat mild, moderate, or severe inflammations, respectively, such as those causing neurological, hematologic, and kidney disorders.
The maximum dose is used, rather than a lower dose, to reduce the number of test subjects (and, among other things, the cost of testing), to detect an effect that might occur only rarely. This type of analysis is also used in establishing chemical residue tolerances in foods. Maximum tolerated dose studies are also done in clinical trials.
In medicine, the total amount of a drug or radiation given to a patient over time; for example, the total dose of radiation given in a series of radiation treatments or imaging exams. Recent studies have drawn attention to high cumulative doses (>100 mSv) to millions of patients undergoing recurrent CT scans during a 1- to 5-year period.
The dose is then slowly tapered over the months. Initially, prednisolone can be reduced by relative large amounts (approximately 10 mg) and smaller amount (2.5–5 mg) subsequently. Should the patient develop flare up of the lesion, the dose should be increased to the previous level or higher and maintained longer before further, slower tapering.
Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol) is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects. [4] [5] [6] It is either used at low doses for chronic illnesses or used concomitantly at high doses during acute flares.
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