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Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]
Estimating or calculating the dietary exposure to a given chemical or contaminant allows a comparison to a relevant health standard such as the acceptable daily intake(ADI), the acute reference dose (ARfD) or a reference dose (RfD), or a level known to cause adverse effects in animal or human health studies. [2]
Tolerable daily intake (TDI) refers to the daily amount of a chemical contaminant that has been assessed safe for human being exposure on long-term basis (usually whole lifetime). [1] TDI specifically occurs to chemicals that humans are exposed to unintentionally or as a contaminant, [ 1 ] where acceptable daily intake refers to chemicals that ...
According to the EPA from 2008, "[a]n aggregate daily exposure to a [chemical] at or below the RfD (expressed as 100 percent or less of the RfD) is generally considered acceptable by EPA." [ 2 ] States can set their own RfDs.
Nitrosamines below this level are acceptable in drugs,” the FDA says on its website. “If drugs contain levels of nitrosamines above the acceptable daily intake limit, FDA recommends these ...
"With a can of diet soft drink containing 200 or 300 mg of aspartame, an adult weighing (154 pounds) would need to consume more than 9–14 cans per day to exceed the acceptable daily intake ...
When consumed in reasonable amounts according to the Food and Drug Administration's acceptable daily intake recommendations, "This is a great option," Susie says. "Because we know that it can add ...
The JECFA makes a distinction between acceptable intakes and tolerable intakes. Tolerable is used to demonstrate permissibility, not acceptability. [3] Substances such as food additives, veterinary drugs, and pesticides that can be controlled in the food supply relatively easily are assessed an acceptable daily intake, or ADI.