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Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]
Estimating or calculating the dietary exposure to a given chemical or contaminant allows a comparison to a relevant health standard such as the acceptable daily intake(ADI), the acute reference dose (ARfD) or a reference dose (RfD), or a level known to cause adverse effects in animal or human health studies. [2]
Tolerable upper intake levels (UL), to caution against excessive intake of nutrients (like vitamin A and selenium) that can be harmful in large amounts. This is the highest level of sustained daily nutrient consumption that is considered to be safe for, and cause no side effects in, 97.5% of healthy individuals in each life stage and sex group.
Tolerable daily intake (TDI) refers to the daily amount of a chemical contaminant that has been assessed safe for human being exposure on long-term basis (usually whole lifetime). [1] TDI specifically occurs to chemicals that humans are exposed to unintentionally or as a contaminant, [ 1 ] where acceptable daily intake refers to chemicals that ...
A reference dose is the United States Environmental Protection Agency's maximum acceptable oral dose of a toxic substance, "below which no adverse noncancer health effects should result from a lifetime of exposure".
The JECFA makes a distinction between acceptable intakes and tolerable intakes. Tolerable is used to demonstrate permissibility, not acceptability. [3] Substances such as food additives, veterinary drugs, and pesticides that can be controlled in the food supply relatively easily are assessed an acceptable daily intake, or ADI.
There is no evidence of carcinogenicity, genotoxicity, neurotoxicity, or reproductive and developmental toxicity at the permitted dietary exposures; the European acceptable daily intake (ADI) is 0.7 mg/kg and the WHO/FAO ADI is 4 mg/kg.
The recommended adequate intake of sodium is 1,500 milligrams (3.9 g salt) per day, and people over 50 need even less." [13] The Daily Value for potassium, 4,700 mg per day, was based on a study of men who were given 14.6 g of sodium chloride per day and treated with potassium supplements until the frequency of salt sensitivity was reduced to 20%.