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Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population, as of 2015. [4] [12] It becomes more common as people age. [1] Among those over 60 years old, about 10% of males and 18% of females are affected. [2] Osteoarthritis is the cause of about 2% of years lived with disability. [12]
The cells targeted for the treatment of osteoarthritis are chondrocytes, synoviocytes, and their progenitors. Since the joint capsule is relatively well contained, intra-articular injections are highly successful at delivering the therapeutic gene therapy locally to the target cell types. Treatment of osteoarthritis may be successful via:
Several approved drugs are being investigated as repurposed agents in the treatment of osteoarthritis such as liraglutide (anti-diabetic and anti-obesity drug: NCT02905864), Metformin (anti-diabetic drug: NCT04767841, NCT05034029), Zoledronic acid (anti-osteoporotic drug: NCT04303026), etc. [4] Paroxetine has been deemed to have DMOAD activity ...
Treatment options vary depending on the type of arthritis and include physical therapy, exercise and diet, orthopedic bracing, and oral and topical medications. [ 2 ] [ 94 ] Joint replacement surgery may be required to repair damage, restore function, or relieve pain.
Cost: $7 | Active ingredients: Lidocaine | Type: Cream | Amount: 4.3 ounces. Lidocaine is another popular ingredient found in pain relief creams. It's a topical anesthetic that's often used to ...
In osteoarthritis, there is a loss of articular hyaluronic acid activity, likely contributing to pain and stiffness associated with the condition. Hyaluronic acid injections are an FDA-approved treatment for osteoarthritis of the knee, and are sometimes also used for other joints. However, the merits of HA injections are still disputed.