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Docetaxel and paclitaxel have comparable efficacy metastatic breast cancer but paclitaxel has less severe side effects. [21] Additionally, it has been noted that docetaxel is prone to cellular drug resistance via a variety of different mechanisms. [22]
TCH is a chemotherapy regimen consisting of Taxotere (docetaxel), carboplatin and Herceptin (trastuzumab), which is used to treat breast cancer. References
Nausea and vomiting are two of the most feared cancer treatment-related side-effects for people with cancer and their families. In 1983, Coates et al. found that people receiving chemotherapy ranked nausea and vomiting as the first and second most severe side-effects, respectively. [98]
Pertuzumab, sold under the brand name Perjeta, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer. [4] Side effects in more than half the people taking it include ...
TAC: Taxotere , Adriamycin (doxorubicin), and cyclophosphamide. [8] FEC: 5-fluorouracil, epirubicin and cyclophosphamide. [9] AT: Adriamycin (doxorubicin) and Taxotere . [3] Since chemotherapy affects the production of white blood cells, a granulocyte colony-stimulating factor (G-CSF) is sometimes administered along with chemotherapy. This has ...
Woman diagnosed with stomach cancer after experiencing severe heartburn. Doctors dismissed her symptoms and the cancer later spread to her ovaries. Woman, 39, thought her severe heartburn was a ...
Mechanism of action of taxanes. The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubules are essential to cell division, and taxanes stabilize GDP-bound tubulin in the microtubule, thereby inhibiting the process of cell division as depolymerization is prevented.
The systems of the body most affected by chemotherapy drugs include visual and semantic memory, attention and motor coordination and executive functioning. [9] [10] These effects can impair a chemotherapy patient's ability to understand and make decisions regarding treatment, perform in school or employment and can reduce quality of life. [10]
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