Search results
Results From The WOW.Com Content Network
Melanoma is the most dangerous type of skin cancer; it develops from the melanin-producing cells known as melanocytes. [1] It typically occurs in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). [1] [2] In women, melanomas most commonly occur on the legs; while in men, on the back. [2]
Most melanoma consist of various colours from shades of brown to black. A small number of melanoma are pink, red or fleshy in colour; these are called amelanotic melanoma and tend to be more aggressive. Warning signs of malignant melanoma include change in the size, shape, color or elevation of a mole.
Superficial spreading melanoma (SSM) is a type of skin cancer that typically starts as an irregularly edged dark spot typically on sun-exposed part of the body. [ 2 ] [ 3 ] The colour may be variable with dark, light and reddish shades; occasionally no color at all. [ 2 ]
The CDKN2A gene is located on chromosome 9p21.3. Two main transcripts, isoforms '1' and '4', each contain three exons and span 7288 and 26740 bp, respectively. They encode proteins of 156 and 173 amino acids; isoform '1' encodes p16(INK4a), while isoform '4' encodes p14(ARF), a protein that is structurally unrelated to p16(INK4) but acts in cell cycle G1 control by stabilizing the tumor ...
Lentigo maligna is a histopathological variant of melanoma in situ. [6] Lentigo maligna is sometimes classified as a very early melanoma, [7] and sometimes as a precursor to melanoma. [8] When malignant melanocytes from a lentigo maligna have invaded below the epidermis, the condition is termed lentigo maligna melanoma. [2]
Those who have light skin, red or blonde hair and light colored eyes are also at increased risk. [ 25 ] Squamous-cell carcinoma of the skin can be found on all areas of the body but is most common on frequently sun-exposed areas, such as the face, legs and arms. [ 68 ]
A guide to Down syndrome including symptoms and diagnosis of this genetic condition.
In the United States there has been an increase in the 5-year relative survival rate between people diagnosed with cancer in 1975-1977 (48.9%) and people diagnosed with cancer in 2007-2013 (69.2%); these figures coincide with a 20% decrease in cancer mortality from 1950 to 2014. [8]