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Nerve compression syndrome, or compression neuropathy, or nerve entrapment syndrome, is a medical condition caused by chronic, direct pressure on a peripheral nerve. [1] It is known colloquially as a trapped nerve, though this may also refer to nerve root compression (by a herniated disc, for example).
Radial neuropathy is a type of mononeuropathy which results from acute trauma to the radial nerve that extends the length of the arm. [3] It is known as transient paresthesia when sensation is temporarily abnormal.
Cervical radiculopathy has an annual incidence rate of 107.3 per 100,000 for men and 63.5 per 100,000 for women, whereas lumbar radiculopathy has a prevalence of approximately 3-5% of the population. [ 26 ] [ 27 ] According to the AHRQ 's 2010 National Statistics for cervical radiculopathy, the most affected age group is between 45 and 64 years ...
Paresthesia is a sensation of the skin that may feel like numbness (technically called hypoesthesia), tingling, pricking, chilling, or burning. [1] It can be temporary or chronic and has many possible underlying causes. [1] Paresthesia is usually painless and can occur anywhere on the body, but most commonly in the arms and legs. [1]
Pressure on the nerves can cause tingling sensations, numbness, pain, weakness, muscle atrophy and even paralysis of the affected area. In normal individuals, these symptoms disappear quickly, but in sufferers of HNPP even a short period of pressure can cause the symptoms to occur. Palsies can last from minutes or days to weeks or even months ...
The amount of pressure required to cause nerve dysfunction starts at around 20mmHg where epineural venus blood flow is reduced. [3] At 30mmHg anterograde and retrograde axonal transport is impaired. [3] Between 30-50mmHg there will usually be changes in intraneural blood flow, axonal transport, and vascular permeability simultaneously. [4]
[3] [8] [5] [2] [6] [4] (The term "meralgia paraesthetica" combines four Greek roots to mean "thigh pain with abnormal sensations".) Examples of paresthesias (abnormal sensations but not unpleasant) and dysthesias (abnormal sensations that are unpleasant) are burning, tingling, numbness, stinging, hypersensitivity, and itching.
Of the vinca alkaloids, the most neurotoxic drug is vincristine. Vincristine disrupts the microtubular axonal transport system, which induces axonal neuropathy, distal numbness and tingling, and pain. [3] 4) Epothilones, mainly ixabepilone, are relatively new drugs that can be used to treat non-small lung, ovarian, and prostate cancers. [3]