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A person consuming a dangerous amount of alcohol persistently can develop memory blackouts and idiosyncratic intoxication or pathological drunkenness symptoms. [36] Long-term persistent consumption of excessive amounts of alcohol can cause liver damage and have other deleterious health effects.
Female subjects on average had a higher percentage of body fat (mean, 26.0; range, 16.7–36.8%) than males (mean, 18.0; range, 10.2–25.3%). [128] Further explanation for the difference in alcohol metabolism between males and females can be found in higher alcohol dehydrogenase activity in female livers.
Alcohol abuse encompasses a spectrum of alcohol-related substance abuse. This spectrum can range from being mild, moderate, or severe. [1] This can look like consumption of more than 2 drinks per day on average for men, or more than 1 drink per day on average for women, to binge drinking. [2]
Symptoms of varying BAC levels. Additional symptoms may occur. The short-term effects of alcohol consumption range from a decrease in anxiety and motor skills and euphoria at lower doses to intoxication (drunkenness), to stupor, unconsciousness, anterograde amnesia (memory "blackouts"), and central nervous system depression at higher doses.
Alcoholic ketoacidosis (AKA) is a specific group of symptoms and metabolic state related to alcohol use. [3] Symptoms often include abdominal pain, vomiting, agitation, a fast respiratory rate, and a specific "fruity" smell. [2] Consciousness is generally normal. [1] Complications may include sudden death. [1]
In 2019, a 25-year-old man presented with symptoms consistent with alcohol intoxication, including dizziness, slurred speech and nausea. He had no prior alcoholic drinks but had a blood alcohol level of 0.3 g/dL. The patient was given 100 mg of the antifungal fluconazole daily for 3 weeks, and his symptoms were resolved. [8]
From 2006 through 2010, there were approximately 87,798 deaths on average attributable to alcohol occurred in the United States each year. [67] Alcohol-related deaths among Americans about doubled from 1999 to 2020. In 2020, alcohol was linked to nearly 50,000 deaths among adults aged 25 to 85, a sharp rise from just under 20,000 in 1999.
Some symptoms such as changes in sleep pattern and gastrointestinal distress are attributed to direct effects of the alcohol intoxication, or withdrawal symptoms. [10] Drowsiness and impaired cognitive function are the two dominant features of alcohol hangover.