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Eplerenone is an antimineralocorticoid, or an antagonist of the mineralocorticoid receptor (MR). [21] Eplerenone is also known chemically as 9,11α-epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone and "was derived from spironolactone by the introduction of a 9α,11α-epoxy bridge and by substitution of the 17α-thoacetyl ...
Water softening is the removal of calcium, magnesium, and certain other metal cations in hard water. The resulting soft water requires less soap for the same cleaning effort, as soap is not wasted bonding with calcium ions. Soft water also extends the lifetime of plumbing by reducing or eliminating scale build-up in pipes
The molecular formula C 24 H 30 O 6 may refer to: Eplerenone , a steroidal antimineralocorticoid of the spirolactone group Estriol triacetate , an estrogen medication and an estrogen ester
Potassium-sparing diuretics act to prevent sodium reabsorption in the collecting tubule by either binding ENaCs (amiloride, triamterene) or by inhibiting aldosterone receptors (spironolactone, eplerenone). This prevents excessive excretion of K + in urine and decreased retention of water, preventing hypokalemia. [10]
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Zeolites are used in laundry detergent as water softeners, removing Ca 2+ and Mg 2+ ions which would otherwise precipitate from the solution. The ions are retained by the zeolites which releases Na + ions into the solution, allowing the laundry detergent to be effective in areas with hard water.
Cationic softeners are incompatible with anionic surfactants in detergents because they combine with them to form a solid precipitate. This requires that the softener be added in the rinse cycle. [6] Fabric softener reduces the absorbency of textiles, which adversely affects the function of towels and microfiber cloth. [7] [failed verification]
This decreases the reabsorption of sodium and water while limiting the excretion of potassium. Hence, aldosterone antagonists are potassium (K + ) sparing diuretics. The medication has a slightly delayed onset of action , and so it takes several days for diuresis to occur since the MR is a nuclear receptor which works through regulating gene ...