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Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in ...
Digoxin increased the risk of death in women by 23%. There was no difference in the death rate for men in the study. [38] Digoxin is also used as a standard control substance to test for P-glycoprotein inhibition. [39] Digoxin appears to be a peripherally selective drug due to limited brain uptake caused by binding to P-glycoprotein. [40] [41]
Cardiac glycosides, such as the commonly used digoxin and digitoxin, deal with the latter, due to their positive inotropic activity. On the other hand, cardiac arrhythmia are changes in heart rate, whether faster ( tachycardia ) or slower ( bradycardia ).
Digoxin helps alleviate symptoms and reduce hospitalizations related to heart failure, but it does not offer any mortality-reducing benefits. [86] Digoxin may be considered in patients who remain symptomatic despite receiving treatment with a first-line combination of an ACE inhibitor (or ARNI ), a beta-blocker , and a mineralocorticoid ...
However, digitoxin, digoxin and several other cardiac glycosides, such as ouabain, have narrow therapeutic windows (i.e., because of their steep dose-response curves, minute increases in the dosage of these drugs can make the difference between an ineffective dose and a fatal one).
Digoxin immune Fab used to treat digoxin toxicity The primary treatment of digoxin toxicity is digoxin immune fab , which is an antibody made up of anti-digoxin immunoglobulin fragments. This antidote has been shown to be highly effective in treating life-threatening signs of digoxin toxicity such as hyperkalemia, hemodynamic instability, and ...
Digitoxin, a phytosteroid and cardiac glycoside found in digitalis. Phytosteroids , also known as plant steroids , are naturally occurring steroids that are found in plants . [ 1 ] Examples include digoxin , digitoxin , diosgenin , and guggulsterone , as well as phytosterols like β-sitosterol and other phytoestrogens like isoflavones .
Digoxin; Magnesium sulfate; Work by other or unknown mechanisms Contraindicated in ventricular arrhythmias; Adenosine is used to treat supraventricular tachycardias, especially in heart failure and atrial fibrillation [9] Magnesium sulfate is used to treat torsades de pointes, a type of arrhythmia