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Treatment for postinflammatory hyperpigmentation may include topical agents like hydroquinone, retinoids, ascorbic acid, and azelaic acid, as well as chemical peels or laser therapy to promote skin renewal and reduce pigmentation. Sun protection is also crucial to prevent further darkening of the affected skin.
The main treatment for acral erythema is discontinuation of the offending drug, and symptomatic treatment to provide analgesia, lessen edema, and prevent superinfection. However, the treatment for the underlying cancer of the patient must not be neglected. Often, the discontinued drug can be substituted with another cancer drug or cancer treatment.
Hypopigmented lesions can range in color from hypopigmentation to depigmentation, and their size, form, and primary inflammatory dermatosis frequently correspond with each other. Complete depigmentation is more noticeable in people with darker skin and is frequently observed in cases of discoid lupus erythematosus and severe atopic dermatitis .
The exact mechanism of various reactions differs, and not all reactions are allergic or immunogenic. [10] In some cases there is inflammatory influx, consistent with leukocytoclastic vasculitis (e.g. infiltrating neutrophils, prominent nuclear dust, lymphocytes and eosinophils with local macrophage infiltration). [ 6 ]
Chemotherapy-induced hyperpigmentation is caused by many chemotherapeutic agents (especially the antibiotics bleomycin, and daunorubicin) and the alkylating agents (cyclophosphamide and busulfan). [ 1 ] : 132
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Erythema (Ancient Greek: ἐρύθημα, from Greek erythros 'red') is redness of the skin or mucous membranes, caused by hyperemia (increased blood flow) in superficial capillaries. [1] It occurs with any skin injury, infection, or inflammation. Examples of erythema not associated with pathology include nervous blushes. [2]
After being diagnosed with stage 4 cancer, the high school football coach and counselor started chemotherapy in 2023, but he had to stop abruptly when the drug he received, cisplatin, became ...