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Animal models indicate that host defense peptides are crucial for both prevention and clearance of infection. It appears as though many peptides initially isolated as and termed "antimicrobial peptides" have been shown to have more significant alternative functions in vivo (e.g. hepcidin [18]). Dusquetide for example is an immunomodulator that ...
Defensin mimetics, also called host defense peptide (HDP) mimetics, are completely synthetic, non-peptide, small molecule structures that mimic defensins in structure and activity. [51] Similar molecules, such as brilacidin , are being developed as antibiotics , [ 52 ] anti-inflammatories for oral mucositis , [ 53 ] [ 54 ] and antifungals ...
When host cells die, either by apoptosis or by cell injury due to an infection, phagocytic cells are responsible for their removal from the affected site. [9] By helping to remove dead cells preceding growth and development of new healthy cells, phagocytosis is an important part of the healing process following tissue injury.
Brilacidin (formerly PMX-30063 [2]), an investigational new drug, is a polymer-based antibiotic currently in human clinical trials, and represents a new class of antibiotics called host defense protein mimetics, or HDP-mimetics, which are non-peptide synthetic small molecules modeled after host defense peptides (HDPs).
Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with sequence CKGGRAKDC-GG-D (KLAKLAK) 2. It is an experimental proapoptotic drug [ 1 ] that has been shown to cause rapid weight loss in mice [ 2 ] and rhesus monkeys. [ 3 ]
The Imd pathway is a broadly-conserved NF-κB immune signalling pathway of insects and some arthropods [1] that regulates a potent antibacterial defence response. The pathway is named after the discovery of a mutation causing severe immune deficiency (the gene was named "Imd" for "immune deficiency").
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