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[2] [1] The cure rates against BV with TOL-463 were said to be comparable to those with recently approved antibiotic treatments like single-dose oral secnidazole (58%) and single-dose metronidazole vaginal gel (41%). [1] As of July 2022, TOL-463 is in phase 2 clinical trials for the treatment of BV and VVC. [3]
Oral antibiotics are administered for a number of days depending on the white blood cell count and the patient's ability to fight off secondary infection. A puppy with minimal symptoms can recover in two or three days if the IV fluids are begun as soon as symptoms are noticed and the CPV test confirms the diagnosis.
Symptoms of both types include vomiting, loss of appetite, depression, and increased drinking and urinating. [1] Fever is seen in less than a third of female dogs with pyometra. [ 2 ] Closed pyometra is a more serious condition than open pyometra not only because there is no outlet for the infection, but also because a diagnosis of closed ...
Metronidazole, sold under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. [10] It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. [10] It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis. [10]
Oral agents adequate for polymicrobial oral infections include the combinations of amoxicillin plus clavulanate, clindamycin and metronidazole plus a macrolide. Penicillin can be added to metronidazole in the treating dental and intracranial infections to cover Actinomyces spp., microaerophilic streptococci, and Arachnia spp.
Symptoms include liver and kidney failure and vasculitis. [10] Lyme disease* is a disease caused by Borrelia burgdorferi, a spirochaete, and spread by ticks of the genus Ixodes. Symptoms in dogs include acute arthritis, anorexia and lethargy. There is no rash as is typically seen in humans. [11]