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Familial atrial fibrillation is an autosomal dominant heart condition that causes disruptions in the heart's normal rhythm. [ 1 ] [ 2 ] This condition is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria ), which causes the heartbeat to become fast and irregular.
Atrial fibrillation is associated with an increased risk of heart failure, dementia, and stroke. [3] [12] It is a type of supraventricular tachycardia. [14] Atrial fibrillation frequently results from bursts of tachycardia that originate in muscle bundles extending from the atrium to the pulmonary veins. [15]
For example, a meta-analysis accomplished in 2018 revealed the discovery of 70 new loci associated with atrial fibrillation. It has been identified different variants associated with transcription factor coding-genes, such as TBX3 and TBX5 , NKX2-5 o PITX2 , which are involved in cardiac conduction regulation, in ionic channel modulation and ...
ARCA has identified common genetic variations that it believes predict individual patient response to Gencaro, giving it the potential to be the first genetically-targeted atrial fibrillation ...
New Adaptive Phase 3 Trial Planned for Gencaro TM in Atrial Fibrillation BROOMFIELD, Colo.--(BUSINESS WIRE)-- ARCA biopharma, Inc. (NAS: ABIO) , a biopharmaceutical company developing genetically ...
Gencaro TM Cardiovascular Effect on Patients with Atrial Fibrillation Paper Published in European Journal of Heart Failure BROOMFIELD, Colo.--(BUSINESS WIRE)-- ARCA biopharma, Inc. (NAS: ABIO ...
The overall effect of each of the genetic variants associated with short QT syndrome is to shorten the cardiac action potential, which in turn increases the risk of developing abnormal heart rhythms including atrial fibrillation and ventricular fibrillation. [2]
Atrial fibrillation is the most common heart rhythm disorder, affecting 2 to 3% of the population of Europe and North America. It is the cause of 20–25% of ischemic brain strokes .