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Tough bundles of collagen called collagen fibers are a major component of the extracellular matrix that supports most tissues and gives cells structure from the outside, but collagen is also found inside certain cells. Collagen has great tensile strength, and is the main component of fascia, cartilage, ligaments, tendons, bone and skin.
Collagen alpha-3(V) chain is a protein that in humans is encoded by the COL5A3 gene. [5] [6] This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains.
Collagen alpha-2(V) chain is a protein that in humans is encoded by the COL5A2 gene. [5] [6] This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains.
After the chains are formed, they arrange into thin fibrils. These collagen fibrils then assort with type I collagen fibrils. [3] Type V collagen is a part of the Extracellular Matrix (ECM). [5] Collagen V is gene expression modulated by TGF-β. Type V collagen has shown that it is resistant to digestion by interstitial collagenases.
Type I collagen is the most abundant collagen of the human body, consisting of around 90% of the body's total collagen in vertebrates. Due to this, it is also the most abundant protein type found in all vertebrates. Type I forms large, eosinophilic fibers known as collagen fibers, which make up most of the rope-like dense connective tissue in ...
12833 Ensembl ENSG00000142156 ENSMUSG00000001119 UniProt P12109 Q04857 RefSeq (mRNA) NM_001848 NM_009933 RefSeq (protein) NP_001839 NP_034063 Location (UCSC) Chr 21: 45.98 – 46.01 Mb Chr 10: 76.54 – 76.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. Function The collagens are a superfamily of ...