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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
The post Why I Started and Stopped Taking the “Anti-Aging” Drug Rapamycin appeared first on AGEIST. I am a healthy sixty-one-year-old man. Addressing my health, fitness, and longevity has been ...
Johnson had been taking rapamycin for five years and stopped last September. “I take this because there’s potentially some longevity benefits,” the 47-year-old explained in his documentary ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
This compound also has a use in cardiovascular drug-eluting stent technologies to inhibit restenosis. [medical citation needed] It is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR). [12]
Sirolimus (rapamycin, rapamune) which is a mTOR (mammalian target of rapamycin) inhibitor [18] can be active in most patients and can in some cases lead to complete or near-complete resolution of autoimmune disease (>90%) [19] [20] With this treatment most patients have complete resolution of lymphoproliferation, including lymphadenopathy and ...
The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. [6] [7] [8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein ...
Sirolimus (also known as rapamycin) is an antifungal and immunosuppressant that has been isolated from S. hygroscopicus from soil samples from Easter Island. [4] Ascomycin is another immunosuppressant produced by some strains of S. hygroscopicus; it has a similar structure to sirolimus and can be used to treat autoimmune diseases and skin diseases and can help prevent rejection after an organ ...