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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
Mechanisms for their modes of activation are unknown and more research is needed to explore and identify new CAPP activators. I 1 PP2A and I 2 PP2A inhibit all possible forms of CAPP by associating with the catalytic subunit using their C-terminal domains (Li, Makkinje, & Damuni, 1996). Both inhibitors are potent and non-competitive (Li et al ...
A protein phosphatase is a phosphatase enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein. Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (), with up to 30% of all proteins being phosphorylated at any given time.
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism.Phosphorylation enables the activation or The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit.
Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits.
5525 226849 Ensembl ENSG00000066027 ENSMUSG00000026626 UniProt Q15172 Q6PD03 RefSeq (mRNA) NM_006243 NM_001199756 NM_144880 RefSeq (protein) NP_001186685 NP_006234 NP_659129 Location (UCSC) Chr 1: 212.29 – 212.36 Mb Chr 1: 191.08 – 191.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme ...
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. [5] [6] Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division.
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