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Infantile hypophosphatasia presents in the first 6 months of life, with the onset of poor feeding and inadequate weight gain. Clinical manifestations of rickets often appear at this time. Although cranial sutures appear to be wide, this reflects hypomineralization of the skull, and there is often "functional" craniosynostosis .
FDA Grants Breakthrough Therapy Designation to Asfotase Alfa for Perinatal-, Infantile- and Juvenile-Onset Hypophosphatasia (HPP) LAUSANNE, Switzerland--(BUSINESS WIRE)-- Alexion Pharma ...
[8] [9] The Stenciling Principle for mineralization is particularly relevant to the osteomalacia and odontomalacia observed in hypophosphatasia (HPP) and X-linked hypophosphatemia (XLH). The most common cause of osteomalacia is a deficiency of vitamin D, which is normally derived from sunlight exposure and, to a lesser extent, from the diet. [10]
In the United States, asfotase alfa is indicated for the treatment of people with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP). [5]In the European Union, asfotase alfa is indicated for long-term enzyme replacement therapy in people with paediatric-onset hypophosphatasia to treat the bone manifestations of the disease.
Dr. Aseem Malhotra, a cardiologist and public health campaigner based in London, says Americans' foods are fueling chronic diseases. He shares his warnings and tips with Fox News Digital.
Infantile hypophosphatasia [102] Intellectual developmental disorder with autistic features and language delay, with or without seizures Microcephaly [103] Intellectual disability, autosomal dominant Microcephaly [104] Intellectual disability, X-linked syndromic, Turner type Brachycephaly, trigonocephaly Macrocephaly or microcephaly
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2 Abstract Although recent legislation has been enacted to require fast-food restaurants to display calorie information on menus, the consequences of posting such information remain unclear.
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