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If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell ...
The Lambda2 method, or Lambda2 vortex criterion, is a vortex core line detection algorithm that can adequately identify vortices from a three-dimensional fluid velocity field. [1] The Lambda2 method is Galilean invariant , which means it produces the same results when a uniform velocity field is added to the existing velocity field or when the ...
596 12043 Ensembl ENSG00000171791 ENSMUSG00000057329 UniProt P10415 P10417 RefSeq (mRNA) NM_000633 NM_000657 NM_009741 NM_177410 RefSeq (protein) NP_000624 NP_000648 NP_033871 NP_803129 Location (UCSC) Chr 18: 63.12 – 63.32 Mb Chr 1: 106.47 – 106.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 ...
Cellular immunity protects the body through: T-cell mediated immunity or T-cell immunity: activating antigen-specific cytotoxic T cells that are able to induce apoptosis in body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. [5] When CD27 binds CD70, a signaling cascade leads to the differentiation and clonal expansion of T cells. [11] The cascade also results in improved survival and memory of cytotoxic T cells and increased production of certain cytokines. [12]
Oscillations are an important type of cell signaling characterized by the periodic change of the system in time. [1] Oscillations can take place in a biological system in a multitude of ways. Positive feedback loops, on their own or in combination with negative feedback are a common feature of oscillating biological systems. [2]
Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation. [6] The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. [7] Alternative splicing results in two transcript variants encoding different ...
This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [7] BAFF is a 285-amino acid long peptide glycoprotein which undergoes glycosylation at residue 124.