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Extrapyramidal side effects, although potentially serious, are infrequent to rare from olanzapine, [43] but may include tremors and muscle rigidity. Aripiprazole , asenapine , clozapine , quetiapine and olanzapine, in comparison to other antipsychotic drugs, are less frequently associated with hyperprolactinaemia .
Common adverse effects of olanzapine, occurring from 1–10%, include: Gynecomastia [8] Extrapyramidal symptoms (EPS) (dose-dependent). Tends to produce less extrapyramidal side effects than typical antipsychotics but more extrapyramidal side effects than sertindole, clozapine and quetiapine. [9] [10]
Note: "Notable" is to mean side-effects that are particularly unique to the antipsychotic drug in question. For example, clozapine is notorious for its ability to cause agranulocytosis. If data on the propensity of a particular drug to cause a particular AE is unavailable an estimation is substituted based on the pharmacologic profile of the drug.
Side effects vary depending on the type of medication used. Some common side effects of bipolar medications include weight gain and fatigue or drowsiness. These side effects can usually be managed ...
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Sexual side effects have also been reported when taking atypical antipsychotics. [55] In males antipsychotics reduce sexual interest, impair sexual performance with the main difficulties being failure to ejaculate. [56] In females there may be abnormal menstrual cycles and infertility. [56]