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Tamsulosin is a selective α 1 receptor antagonist that has preferential selectivity for the α 1A receptor in the prostate versus the α 1B receptor in the blood vessels. [ 25 ] When alpha 1 receptors in the bladder neck, prostate, ureter, and urethra are blocked, a relaxation in smooth muscle tissue results. [ 16 ]
The prostate is a gland that is found under the rectum and below the bladder in the male reproductive system. [5] Five randomized controlled trials were conducted to determine whether prostate cancer screening reduces mortality associated with prostate cancer where 341,342 participants within the age range of 45–80 years were included in the ...
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. [1] Symptoms may include frequent urination, trouble starting to urinate, weak stream, inability to urinate, or loss of bladder control. [1]
Saw palmetto extract has been studied in clinical trials as a possible treatment for people with prostate cancer and for men with lower urinary tract symptoms associated with BPH. [1] [3] As of 2023, there is insufficient scientific evidence that saw palmetto extract is effective for treating cancer or BPH and its symptoms.
Alpha-1 blockers are first line treatment for the symptoms of BPH in men. [1] [2] [7] [8] Doxazosin, terazosin, alfuzosin, and tamsulosin have all been well established in treatment to reduce lower urine tract symptoms (LUTS) caused by benign prostatic hyperplasia. They are all believed to be similarly effective for this purpose.
The role of the prostate was questioned in the cause of CP/CPPS when both men and women in the general population were tested using the (1) National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI [92]) – with the female homologue of each male anatomical term used on questionnaires for female participants – (2) the ...
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