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Cardiomyocyte hypertrophy occurs through sarcomerogenesis, the creation of new sarcomere units in the cell. During heart volume overload, cardiomyocytes grow through eccentric hypertrophy. [ 27 ] The cardiomyocytes extend lengthwise but have the same diameter, resulting in ventricular dilation.
Cardiomyocyte proliferation refers to the ability of cardiac muscle cells to progress through the cell cycle and continue to divide. Traditionally, cardiomyocytes were believed to have little to no ability to proliferate and regenerate after birth. [ 1 ]
Basic cardiac action potential. Unlike the action potential in skeletal muscle cells, the cardiac action potential is not initiated by nervous activity.Instead, it arises from a group of specialized cells known as pacemaker cells, that have automatic action potential generation capability.
In electrocardiography, the ventricular cardiomyocyte membrane potential is about −90 mV at rest, [1] which is close to the potassium reversal potential. When an action potential is generated, the membrane potential rises above this level in five distinct phases. [1] Phase 4: Resting membrane potential remains stable at ≈−90 mV. [1]
A muscle cell, also known as a myocyte, is a mature contractile cell in the muscle of an animal. [1] In humans and other vertebrates there are three types: skeletal, smooth, and cardiac (cardiomyocytes). [2]
The sarcolemma (sarco (from sarx) from Greek; flesh, and lemma from Greek; sheath), also called the myolemma, is the cell membrane surrounding a skeletal muscle fibre or a cardiomyocyte. [1] [2] It consists of a lipid bilayer and a thin outer coat of polysaccharide material that contacts the basement membrane.
Within the muscle tissue of animals and humans, contraction and relaxation of the muscle cells is a highly regulated and rhythmic process.In cardiomyocytes, or cardiac muscle cells, muscular contraction takes place due to movement at a structure referred to as the diad, sometimes spelled "dyad."
Myocardial contractility represents the innate ability of the heart muscle (cardiac muscle or myocardium) to contract.It is the maximum attainable value for the force of contraction of a given heart.