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Hans Christian Joachim Gram (13 September 1853 – 14 November 1938) was a Danish bacteriologist noted for his development of the Gram stain, still a standard technique to classify bacteria and make them more visible under a microscope.
Antonie Philips van Leeuwenhoek [note 2] FRS (/ ˈ ɑː n t ə n i v ɑː n ˈ l eɪ v ən h uː k,-h ʊ k / AHN-tə-nee vahn LAY-vən-hook, -huuk; Dutch: [ˈɑntoːni vɑn ˈleːu.ə(n)ˌɦuk] ⓘ; 24 October 1632 – 26 August 1723) was a Dutch microbiologist and microscopist in the Golden Age of Dutch science and technology.
Griffith's experiment discovering the "transforming principle" in Streptococcus pneumoniae (pneumococcal) bacteria. Griffith's experiment, [1] performed by Frederick Griffith and reported in 1928, [2] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.
Gram staining is almost always the first step in the identification of a bacterial group. While Gram staining is a valuable diagnostic tool in both clinical and research settings, not all bacteria can be definitively classified by this technique. This gives rise to gram-variable and gram-indeterminate groups.
Bacteriology is the study of bacteria and their relation to medicine. Bacteriology evolved from physicians needing to apply the germ theory to address the concerns relating to disease spreading in hospitals the 19th century. [5] Identification and characterizing of bacteria being associated to diseases led to advances in pathogenic bacteriology.
Heinrich Hermann Robert Koch (/ k ɒ x / KOKH; [1] [2] German: [ˈʁoːbɛʁt ˈkɔx] ⓘ; 11 December 1843 – 27 May 1910) was a German physician and microbiologist.As the discoverer of the specific causative agents of deadly infectious diseases including tuberculosis, cholera and anthrax, he is regarded as one of the main founders of modern bacteriology.
Dallinger was one of the first to carry out a controlled evolution experiment. In the late 19th century, he cultivated small unicellular organisms in a custom-built incubator over a time period of seven years (1880–1886). Dallinger slowly increased the temperature of the incubator from an initial 60 °F up to 158 °F.
Robert Hooke, using a microscope, observes cells (1665). Anton van Leeuwenhoek discovers microorganisms (1674–1676). James Lind, publishes 'A Treatise of the Scurvy' which describes a controlled shipboard experiment using two identical populations but with only one variable, the consumption of citrus fruit (1753).