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A G cell or gastrin cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells. G cells are found deep within the pyloric glands of the stomach antrum, and occasionally in the pancreas [1] and duodenum. The vagus nerve innervates the G cells.
Gastrin is a linear peptide hormone produced by G cells of the duodenum and in the pyloric antrum of the stomach.It is secreted into the bloodstream. The encoded polypeptide is preprogastrin, which is cleaved by enzymes in posttranslational modification to produce progastrin (an intermediate, inactive precursor) and then gastrin in various forms, primarily the following three:
Enteroendocrine cells are specialized cells of the gastrointestinal tract and pancreas with endocrine function. They produce gastrointestinal hormones or peptides in response to various stimuli and release them into the bloodstream for systemic effect, diffuse them as local messengers, or transmit them to the enteric nervous system to activate nervous responses.
Gastrin: G Cells in stomach ECL cells; parietal cells None Increases acid secretion, increases mucus growth Stimulates gastric contraction None Peptides and amino acids in lumen; gastrin releasing peptide and ACh in nervous reflexes Cholecystokinin (CCK) Endocrine I cells of the small intestine; neurons of the brain and gut
Both forms of gastrin are found in the gastric antrum and duodenum: Gastrins stimulate the secretion of gastric acid, pepsinogen, intrinsic factor, and secretin; stimulate intestinal mucosal growth; increase gastric and intestinal motility Big gastrin: 3839: 34: Secretin-glucagon family: Secretin: 3056: 27: Duodenum and jejunum
Histamine is a paracrine secretion from the enteroendocrine cells in the gastric glands. Gastrin is a hormone produced by enteroendocrine G cells in the pyloric glands. [1] All three of these stimulate parietal cells to secrete hydrochloric acid and intrinsic factor. The chief cells secrete pepsinogen in response to gastrin and especially Ach ...
Diagram showing gastric pits (13) gastric glands (12) lamina propria (10) epithelium (11) Histology of normal fundic mucosa. Fundic glands are simple, branched tubular glands that extend from the bottom of the gastric pits to the muscularis mucosae; the more distinctive cells are parietal cells. H&E stain.
In 1905, John Sydney Edkins demonstrated the existence of a hormone responsible for the secretion of gastric acid. [4] This hormone was named gastric secretin or gastrin. But it was not until 1979 and later in 1987 and 1988 that progastrin was identified as the precursor to gastrin. [5] [6] [7] His protein sequence and mRNA were revealed.