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Hormone or peptide Major tissue locations in the gut Principal known actions Bombesin: Throughout the gut and pancreas: Stimulates release of cholecystokinin (CCK) and gastrin Calcitonin gene-related peptide: Enteric nerves: Unclear Chromogranin A: Neuroendocrine cells: Secretory protein Enkephalins: Stomach, duodenum: Opiate-like actions ...
Gastrin is a linear peptide hormone produced by G cells of the duodenum and in the pyloric antrum of the stomach.It is secreted into the bloodstream. The encoded polypeptide is preprogastrin, which is cleaved by enzymes in posttranslational modification to produce progastrin (an intermediate, inactive precursor) and then gastrin in various forms, primarily the following three:
A G cell or gastrin cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells. G cells are found deep within the pyloric glands of the stomach antrum, and occasionally in the pancreas [1] and duodenum. The vagus nerve innervates the G cells.
Enteroendocrine cells are specialized cells of the gastrointestinal tract and pancreas with endocrine function. They produce gastrointestinal hormones or peptides in response to various stimuli and release them into the bloodstream for systemic effect, diffuse them as local messengers, or transmit them to the enteric nervous system to activate nervous responses.
The effects range from excitatory or inhibitory effects on motility and secretion to feelings of satiety or hunger when acting on the brain. These hormones fall into three major categories, the gastrin and secretin families, with the third composed of all the other hormones unlike those in the other two families. Further information on the GI ...
A peptide hormone, gastrin, produced by G cells in the gastric glands, stimulates the production of gastric juice which activates the digestive enzymes. Pepsinogen is a precursor enzyme produced by the gastric chief cells, and gastric acid activates this to the enzyme pepsin which begins the digestion of proteins. As these two chemicals would ...
G cells – They secrete gastrin hormone. Gastrin stimulates the gastric glands to release gastric acid. These cells are mostly found in pyloric glands in the pyloric antrum; some are found in the duodenum and other tissues. The gastric pits of these glands are much deeper than the others and here the gastrin is secreted into the bloodstream ...
These cells are stimulated by the hormones gastrin (not depicted in the adjacent diagram) and pituitary adenylyl cyclase-activating peptide. G cells are stimulated by vagal stimulation through the neurotransmitter gastrin-releasing peptide ; this causes the G cells to secrete gastrin, which in turn stimulates ECL cells to release histamine.