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The mediastinum has three main parts: the anterior mediastinum (front), the middle mediastinum, and the posterior mediastinum (back). Masses in the anterior portion of the mediastinum can include thymoma, lymphoma , pheochromocytoma , germ cell tumors including teratoma , thyroid tissue, and parathyroid lesions.
[2] [7] Pericardial cysts make up 6-7% of all mediastinal masses. [ 2 ] [ 3 ] They can present at any age, but are most commonly diagnosed between the third and fifth decade of life. [ 2 ] [ 3 ] Females and males have approximately equal incidences of pericardial cysts.
The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass. In addition to physical examination and routine laboratory studies, initial evaluation should include CT of the chest and abdomen, and determination of serum levels of HCG and alpha-fetoprotein.
Patients often present with extensive bone marrow involvement, mediastinal mass, adenopathy, CNS involvement, and splenomegaly. [1] The symptoms can appear acutely or develop progressively over time. The most common clinical feature among patients is the proliferation of malignant clones, suppressing normal haematopoiesis and resulting in a ...
Primary mediastinal B-cell lymphoma, abbreviated PMBL or PMBCL, is a rare type of lymphoma that forms in the mediastinum (the space in between the lungs) and predominantly affects young adults. [ 1 ] [ 2 ] [ 3 ]
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Micrograph of a primary mediastinal large B-cell lymphoma, a cause of mediastinal lymphadenopathy. H&E stain. Mediastinal lymphadenopathy or mediastinal adenopathy is an enlargement of the mediastinal lymph nodes.
Pain on the right side under the ribs isn’t always a sign of a serious problem, but here are possible causes and when to see a doctor. ... Is right rib pain a sign of something serious? When to ...