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Microorganisms may be a viable solution to this issue of environmental pollution by the degradation of the xenobiotics; a process known as bioremediation. [9] Microorganisms are able to adapt to xenobiotics introduced into the environment through horizontal gene transfer, in order to make use of such compounds as energy sources. [8]
Pharmaceutical drugs are chemicals used for the alteration, diagnosis, prevention and treatment of disease, health conditions or structure/function of the human body. Some pharmaceutically active compounds (PhACs) can enter the environment by one route or another as the parent compound or as pharmacologically active metabolites .
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
Advanced Placement (AP) Human Geography (also known as AP Human Geo, AP Geography, APHG, AP HuGe, APHug, AP Human, HuGS, AP HuGo, or HGAP) is an Advanced Placement social studies course in human geography for high school, usually freshmen students in the US, culminating in an exam administered by the College Board.
Original mapping by John Snow showing the clusters of cholera cases in the London epidemic of 1854, which is a classical case of using human geography. Human geography or anthropogeography is the branch of geography which studies spatial relationships between human communities, cultures, economies, and their interactions with the environment, examples of which include urban sprawl and urban ...
A xenobiotic-sensing receptor is a receptor that binds xenobiotics. [1] They include the following nuclear receptors: [1] Constitutive androstane receptor (CAR) Pregnane X receptor (PXR) CAR and PXR are xenobiotic receptors and they both are members of NR1I nuclear receptor family. The regulate the metabolic pathway for the elimination of ...
Environmental degradation is the deterioration of the environment through depletion of resources such as quality of air, water and soil; the destruction of ecosystems; habitat destruction; the extinction of wildlife; and pollution. It is defined as any change or disturbance to the environment perceived to be deleterious or undesirable.