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In this case, cystatin C-based estimates of GFR, eGFR cystatin C, will be lower than creatinine-based estimates eGFR creatinine, so that a hypothesized condition, named shrunken pore syndrome, is identified by a low eGFR cystatin C /eGFR creatinine-ratio. [medical citation needed] [55] This syndrome is associated with a very strong increase in ...
After filtration, Cystatin C is reabsorbed and catabolized by the tubular epithelial cells, with only small amounts excreted in the urine. Cystatin C levels are therefore measured not in the urine, but in the bloodstream. Equations have been developed linking estimated GFR to serum cystatin C levels. [15]
The functions of the kidney include maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules; regulation of blood pressure; production of various hormones, such as erythropoietin; and activation of vitamin D.
Cystatin C is a protein that is freely filtered in the glomeruli before it is reabsorbed and catabolized in the renal tubular cells. Its serum level is independent of muscle mass, making more accurate at estimating GFR than creatinine serum levels.
An increase in serum creatinine can be due to increased ingestion of cooked meat (which contains creatinine converted from creatine by the heat from cooking) or excessive intake of protein and creatine supplements, taken to enhance athletic performance. Intense exercise can increase creatinine by increasing muscle breakdown.
n/a Ensembl ENSG00000170369 n/a UniProt P09228 n/a RefSeq (mRNA) NM_001322 n/a RefSeq (protein) NP_001313 n/a Location (UCSC) Chr 20: 23.82 – 23.83 Mb n/a PubMed search n/a Wikidata View/Edit Human Cystatin-SA is a protein that in humans is encoded by the CST2 gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active ...
This comparative procedure allowed the definition of a new type of kidney disorder characterized by a greater reduction of renal clearances of larger molecules (e.g. cystatin C, 13,343Da) than of smaller ones (e.g. creatinine, 113Da) and identified by a greater reduction of the cystatin C-based GFR-estimate (eGFR cystatin C) than that based ...
Testing often includes blood tests such as a complete blood count, a basic metabolic panel, and an assessment of cystatin c. [20] Additionally, urodynamic testing and a kidney bladder ultrasound are typically performed to assess characteristics of the urinary tract prior to surgery. [20]