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CIPN involves various symptoms such as tingling, pain, and numbness in the hands and feet. [2] These symptoms can impair activities of daily living, such as typing or dressing, reduce balance, and increase risk of falls and hospitalizations. They can also give cause to reduce or discontinue chemotherapy.
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
Causes painful defecation, constipation; may be complicated by encopresis or fecal incontinence. Cervical dystonia (spasmodic torticollis) muscles of the neck: Causes the head to rotate to one side, to pull down towards the chest, or back, or a combination of these postures. Blepharospasm: muscles around the eyes
Polyneuropathy (from Greek poly- 'many' neuro- 'nerve' and -pathy 'sickness') is damage or disease affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, and burning pain. [1]
Muscle cramps could also potentially stem from a nerve problem (such as nerve compression), exercising in the heat, a lack of stretching, muscle fatigue, body stress, medication side effects or ...
The study also included a reference arm of 100 milligram dose of pregabalin, also known as Lyrica, a medication that treats nerve pain. Vertex plans to advance the drug to a late-stage trial ...
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