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It is an uncommon low-grade malignant lung mass that is most often in the central airways of the lung. It is also known as "atypical lung carcinoid tumour", " atypical lung carcinoid" or "moderately differentiated neuroendocrine carcinoma". It is a more aggressive than typical carcinoid tumors: nodal metastases in 70% vs. 5%.
By definition, they are greater than 4 mm in largest dimension; smaller lesions are referred to as pulmonary carcinoid tumourlets. [citation needed] The differential diagnosis of typical pulmonary carcinoid tumour includes: atypical pulmonary carcinoid tumour, pulmonary carcinoid tumourlet and lung adenocarcinoma. [citation needed]
Due to presence of these tumors, DIPNECH is classified as a pre-malignant condition. [1] Although there have been reports of atypical carcinoids with local lymph node involvement, there are no reports of more aggressive neuroendocrine tumors, such as large cell neuroendocrine or small cell lung cancer, associated with DIPNECH. [3]
Atypical pulmonary carcinoid tumour; References External links. Lung carcinoids (cancer.org) ... Lung carcinoids (cancer.org) This page was last edited on 2 October ...
Parathyroid tumors; Thymus and mediastinal carcinoid tumors [11] [12] Pulmonary neuroendocrine tumors [13] [14] bronchus [12] pulmonary carcinoid tumors: typical carcinoid (TC; low-grade); atypical carcinoid (AC; intermediate-grade) small-cell lung cancer (SCLC) large cell neuroendocrine carcinoma of the lung (LCNEC) [15]
Chemotherapy for NSCLC usually includes combination of two drugs (chemotherapy doublet), with one of the agents is cisplatin or carboplatin. In 2002, Schiller at al. published in the New England Journal of Medicine, a study that compared four chemotherapy regimens for advanced NSCLC, cisplatin and paclitaxel, cisplatin and gemcitabine, cisplatin and docetaxel, and carboplatin and paclitaxel. [14]
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