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C. asiatica has been shown to activate telomerase more than any other known compound yet discovered: 8.8-fold. This exceeds the activation by other known telomerase activators: oleanolic acid 5.9-fold, Astragalus extract 4.3-fold, TA-65 2.2-fold, and maslinic acid 2-fold. [17]
Cycloastragenol is a triterpenoid isolated from various legume species in the genus Astragalus that is purported to have telomerase activation activity. A preliminary in vitro study on human CD4 and CD8 T cells found that cycloastragenol may moderately increase telomerase activity and inhibit the onset of cellular senescence. [1]
Oleanolic acid activates telomerase in peripheral blood mononuclear cells (PBMCs) 5.9-fold, more than any other compounded tested, with the exception of Centella asiatica (8.8-fold). [14] Less telomerase activation is seen for Astragalus extract 4.3-fold, TA-65 2.2-fold, and maslinic acid 2-fold. [14]
The company is in the early stages of developing a telomerase based treatment for HIV called TAT0002, which is the saponin cycloastragenol in Chinese herb Astragalus propinquus. [25] Geron has granted a license to Telomerase Activation Sciences to sell TA-65 , the telomerase activator agent also derived from astragalus . [ 26 ]
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The leaves are used as herbal medicine to alleviate cough and fever, pain, and general gastrointestinal disorders as well as to cure dermatologic disorders. Similarly, the fruit juice and oils can be used in the treatment of liver disease, gastrointestinal disorders, chronic wounds or other dermatological disorders.
Betulinic acid induces apoptosis by direct effects on mitochondria, leading to cytochrome c release, which in turn regulates the "downstream" caspase activation. [11] Betulinic acid bypasses resistance to CD95 and doxorubicin -mediated apoptosis, due to different molecular mechanism of betulinic acid-induced apoptosis.
The best herbs for stress and anxiety There are a lot of different herbs that may help with stress and anxiety. Consider these options, and keep in mind that experts agree to check with your ...