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Taconic Biosciences is a private biotechnology company specializing in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services. The company was founded in 1952 as Taconic Farms.
Many laboratory animals, including mice and rats, are chronically stressed which can also negatively affect research outcomes and the ability to accurately extrapolate findings to humans. [32] [33] Researchers have also noted that many studies involving mice, rats and other rodents are poorly designed, leading to questionable findings.
The albino laboratory mouse is an iconic model organism for scientific research in a variety of fields An SCID Intermediate coat colour Kept as a pet. The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets.
The activated oncogene significantly increases the mouse's susceptibility to cancer, and thus makes the mouse a suitable model for cancer research. [2] [3] OncoMouse was not the first transgenic mouse to be developed for use in cancer research. Ralph L. Brinster and Richard Palmiter had developed such mice previously. However, OncoMouse was the ...
A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases and are also used for research on genes.
Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson's disease. Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.
An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human. Although biological activity in an animal model does not ensure an effect in humans ...
This is, in part, because different stakeholders (e.g. animal experimenters, institutional figures, policy makers, activists and the public) may interpret the Three Rs differently. [ 19 ] [ 20 ] The 3Rs principles do not address some issues, such as the ethics of using animals in research and focus instead on improving the humane use of animals ...