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Gas gangreneX (also known as clostridial myonecrosis [1]) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. About 1,000 cases of gas gangrene are reported yearly in the United States. [2] Myonecrosis is a condition of necrotic damage, specific to ...
Gas gangrene is a bacterial infection that produces gas within tissues. It can be caused by Clostridium , most commonly alpha toxin -producing C. perfringens , or various nonclostridial species. [ 11 ] [ 21 ] Infection spreads rapidly as the gases produced by the bacteria expand and infiltrate healthy tissue in the vicinity.
This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
The two most prominent infections of GAS are both non-invasive: strep throat (pharyngitis) where it causes 15–30% of the childhood cases and 10% of adult cases, and impetigo. [4] These may be effectively treated with antibiotics. Scarlet fever is also a non-invasive infection caused by GAS, although much less common.
Note the tense wall indicative of gas under pressure and volvulus. Bowel infarction or gangrenous bowel represents an irreversible injury to the intestine resulting from insufficient blood flow. It is considered a medical emergency because it can quickly result in life-threatening infection and death. [ 1 ]
Hathewaya histolytica can cause gas gangrene, an acute infection of pain, fever, myonecrosis, and massive edema. If not controlled, the infection can result in systemic toxemia, multiorgan failure, and even death. Further, this infection can progress to life-threatening in a matter of hours. [11]
Necrotizing pneumonia (NP), also known as cavitary pneumonia or cavitatory necrosis, is a rare but severe complication of lung parenchymal infection. [ 1 ] [ 2 ] [ 3 ] In necrotizing pneumonia, there is a substantial liquefaction following death of the lung tissue, which may lead to gangrene formation in the lung.
Gangrene of the skin: ... Dermatitis gangrenosa is a cutaneous condition caused by infection by Clostridium resulting in a necrosis and sloughing of the skin. [1]: ...