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It is a crystalline acid obtained by hydrolysis of allantoin. In nature, allantoic acid is produced from allantoin by the enzyme allantoinase (encoded by the gene AllB ( Uniprot : P77671 ) in Escherichia coli and other bacteria ).
SGLT2 inhibitors are used in the treatment of type 2 diabetes. Apart from blood sugar control, gliflozins have been shown to provide significant cardiovascular benefit in people with type 2 diabetes. [2] [3] As of 2014, several medications of this class had been approved or were under development. [4]
Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin , most GLP-1 receptor agonists ( liraglutide , exenatide , and others), and pramlintide , all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
Semaglutide is an anti-diabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management. [ 23 ] [ 24 ] [ 25 ] It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain .
Allantoin is a chemical compound with formula C 4 H 6 N 4 O 3.It is also called 5-ureidohydantoin or glyoxyldiureide. [1] [2] It is a diureide of glyoxylic acid.Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria, though not humans.
A 2020 Cochrane systematic review did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease when comparing metformin monotherapy to dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes.
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