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Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . [ 5 ]
In terms of total mass, myelin comprises approximately 40% water; the dry mass comprises between 60% and 75% lipid and between 15% and 25% protein. Protein content includes myelin basic protein (MBP), [21] which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte ...
Activation of macrophages and lymphocytes and their migration across the barrier may result in direct attacks on myelin sheaths within the central nervous system, leading to the characteristic demyelination event observed in MS. [59] After demyelination has occurred, the degraded myelin sheath components, such as myelin basic proteins and ...
18857 Ensembl ENSG00000147588 ENSMUSG00000052468 UniProt P02689 P24526 RefSeq (mRNA) NM_002677 NM_001348381 NM_001030305 RefSeq (protein) NP_002668 NP_001335310 NP_001025476 Location (UCSC) Chr 8: 81.44 – 81.45 Mb Chr 3: 10.24 – 10.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene. Myelin protein P2 is a ...
Myelin is formed by oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system.Therefore, the first stage of myelinogenesis is often defined as the differentiation of oligodendrocyte progenitor cells (OPCs) or Schwann cell progenitors into their mature counterparts, [4] followed by myelin formation around axons.
In neurobiology, Hood and his colleagues were the first to clone and study the myelin basic protein (MBP) gene. The MBP is a central component in the sheath that wraps and protects neurons. [98] [99] Hood demonstrated that the condition called "shiverer mouse" arose from a defect in the MBP gene. Hood's research group corrected the neurological ...
They differentiate into the less mobile premyelinating oligodendrocytes that further differentiate into oligodendrocytes, [35] a process characterized by the emergence of the expression of myelin basic protein (MBP), proteolipid protein (PLP), or myelin-associated glycoprotein (MAG). [28]
Glatiramer acetate is a mixture of random polymers of four amino acids which is antigenically similar to the myelin basic protein, a component of the myelin sheath of nerves with which it competes for presentation to T cells . It is injected subcutaneously on a daily basis.