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Lidocaine/prilocaine is a eutectic mixture of equal quantities (by weight) of lidocaine and prilocaine. A 5% emulsion preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by APP Pharmaceuticals under the trade name EMLA (an abbreviation for Eutectic Mixture of Local Anesthetics ). [ 5 ]
Lidocaine is an antiarrhythmic medication of the class Ib type. [7] This means it works by blocking sodium channels thus decreasing the rate of contractions of the heart. [10] [7] When injected near nerves, the nerves cannot conduct signals to or from the brain. [8] Lidocaine was discovered in 1946 and went on sale in 1948. [11]
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
A topical anesthetic is a local anesthetic that is used to numb the surface of a body part. They can be used to numb any area of the skin as well as the front of the eyeball, the inside of the nose, ear or throat, the anus and the genital area. [1]
Topical gels are commonly used as sustained release dosage forms. [5] [9] Usage of the sustained release dosage form reduces the administration of recurrent doses while maintaining serum dose levels at the therapeutic range (difference between toxic and therapeutic doses), hence improving patient compliance. [5]
Ketoprofen can also be used for treatment of some pain, especially nerve pain such as sciatica, postherpetic neuralgia and referred pain for radiculopathy, in the form of a cream, ointment, liquid, spray, or gel, which may also contain ketamine and lidocaine, along with other agents which may be useful, such as cyclobenzaprine, amitriptyline ...
Laser-assisted drug delivery (LADD) is a drug delivery technique commonly used in the dermatology field that involves lasers. As skin acts as a protective barrier to the environment, the absorption of topical products through the epidermis is limited; thus, different drug delivery modalities have been employed to improve the efficacy of these treatments.
[50] [51] Chemicals used in disinfectants vary in forms, such as gel, liquid, and powder. [52] [53] Minimal information remains about the health and safety of workers in other sectors of the production and manufacturing process of disinfectants. Inspection is a process of disinfectant manufacturing that only requires human intervention. [50]